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Cytochrome P450 3A4 Anagrelide Anagrelide Anagrelide PIS1M1 Anagrelide PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Anagrelide undergoes metabolism to give Anagrelide PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Anagrelide Anagrelide Anagrelide PIS1M1 Anagrelide PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Bl Bl Ana PIS Ana PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Anagrelide undergoes metabolism to give Anagrelide PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Bl Bl Ana PIS Ana PIS U E a B