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Cytochrome P450 3A4 Avacopan Avacopan Avacopan PIS1M1 Avacopan PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Avacopan undergoes metabolism to give Avacopan PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Avacopan Avacopan Avacopan PIS1M1 Avacopan PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Avaco Avaco Ava PIS Ava PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Avacopan undergoes metabolism to give Avacopan PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Avaco Avaco Ava PIS Ava PIS U E a B