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Cytochrome P450 3A4 Bimatoprost Bimatoprost Bimatoprost PIS1M1 Bimatoprost PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Bimatoprost undergoes metabolism to give Bimatoprost PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Bimatoprost Bimatoprost Bimatoprost PIS1M1 Bimatoprost PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Agn Agn Bim PIS Bim PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Bimatoprost undergoes metabolism to give Bimatoprost PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Agn Agn Bim PIS Bim PIS U E a B