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Cytochrome P450 3A4 Clonidine Clonidine Clonidine PIS1M1 Clonidine PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Clonidine undergoes metabolism to give Clonidine PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Clonidine Clonidine Clonidine PIS1M1 Clonidine PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Clonidi Clonidi Clo PIS Clo PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Clonidine undergoes metabolism to give Clonidine PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Clonidi Clonidi Clo PIS Clo PIS U E a B