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Cytochrome P450 3A4 Crizotinib Crizotinib Crizotinib PIS1M1 Crizotinib PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Crizotinib undergoes metabolism to give Crizotinib PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Crizotinib Crizotinib Crizotinib PIS1M1 Crizotinib PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Crizo Crizo Cri PIS Cri PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Crizotinib undergoes metabolism to give Crizotinib PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Crizo Crizo Cri PIS Cri PIS U E a B