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Cytochrome P450 3A4 Ivosidenib Ivosidenib Ivosidenib PIS1M1 Ivosidenib PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Ivosidenib undergoes metabolism to give Ivosidenib PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Ivosidenib Ivosidenib Ivosidenib PIS1M1 Ivosidenib PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Ivosi Ivosi Ivo PIS Ivo PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Ivosidenib undergoes metabolism to give Ivosidenib PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Ivosi Ivosi Ivo PIS Ivo PIS U E a B