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Cytochrome P450 3A4 Mitapivat Mitapivat Mitapivat PIS1M1 Mitapivat PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Mitapivat undergoes metabolism to give Mitapivat PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Mitapivat Mitapivat Mitapivat PIS1M1 Mitapivat PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Mitap Mitap Mit PIS Mit PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Mitapivat undergoes metabolism to give Mitapivat PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Mitap Mitap Mit PIS Mit PIS U E a B