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Cytochrome P450 3A4 Naldemedine Naldemedine Naldemedine PIS1M1 Naldemedine PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Naldemedine undergoes metabolism to give Naldemedine PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Naldemedine Naldemedine Naldemedine PIS1M1 Naldemedine PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Nalde Nalde Nal PIS Nal PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Naldemedine undergoes metabolism to give Naldemedine PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Nalde Nalde Nal PIS Nal PIS U E a B