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Cytochrome P450 3A4 Nalmefene Nalmefene Nalmefene PIS1M1 Nalmefene PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Nalmefene undergoes metabolism to give Nalmefene PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Nalmefene Nalmefene Nalmefene PIS1M1 Nalmefene PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Nalme Nalme Nal PIS Nal PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Nalmefene undergoes metabolism to give Nalmefene PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Nalme Nalme Nal PIS Nal PIS U E a B