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Cytochrome P450 3A4 Ribociclib Ribociclib Ribociclib PIS1M1 Ribociclib PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Ribociclib undergoes metabolism to give Ribociclib PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Ribociclib Ribociclib Ribociclib PIS1M1 Ribociclib PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Riboc Riboc Rib PIS Rib PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Ribociclib undergoes metabolism to give Ribociclib PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Riboc Riboc Rib PIS Rib PIS U E a B