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Cytochrome P450 3A4 Sertraline Sertraline Sertraline PIS1M1 Sertraline PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Sertraline undergoes metabolism to give Sertraline PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Sertraline Sertraline Sertraline PIS1M1 Sertraline PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Zoloft Zoloft Ser PIS Ser PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Sertraline undergoes metabolism to give Sertraline PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Zoloft Zoloft Ser PIS Ser PIS U E a B