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Cytochrome P450 3A4 Sulindac Sulindac Sulindac PIS1M1 Sulindac PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Sulindac undergoes metabolism to give Sulindac PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Sulindac Sulindac Sulindac PIS1M1 Sulindac PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Sd Sd Sul PIS Sul PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Sulindac undergoes metabolism to give Sulindac PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Sd Sd Sul PIS Sul PIS U E a B