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Cytochrome P450 3A4 Tadalafil Tadalafil Tadalafil PIS1M1 Tadalafil PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Tadalafil undergoes metabolism to give Tadalafil PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Tadalafil Tadalafil Tadalafil PIS1M1 Tadalafil PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Cialis Cialis Tad PIS Tad PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Tadalafil undergoes metabolism to give Tadalafil PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Cialis Cialis Tad PIS Tad PIS U E a B