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Cytochrome P450 3A4 Trifarotene Trifarotene Trifarotene PIS1M1 Trifarotene PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Trifarotene undergoes metabolism to give Trifarotene PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
CYP3A4 Trifa Trifa Tri PIS Tri PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Trifarotene undergoes metabolism to give Trifarotene PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Trifa Trifa Tri PIS Tri PIS U E a B