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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Amprenavir PIS2M1 Amprenavir Amprenavir Amprenavir PIS1M1 Amprenavir PIS2M1 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Amprenavir undergoes metabolism to give Amprenavir PIS1M1 and Amprenavir PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 Amprenavir PIS2M1 Amprenavir Amprenavir Amprenavir PIS1M1 Amprenavir PIS2M1 Urinary Excretion and/or Bile duct Excretion