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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cladribine PIS2M1 Cladribine Cladribine Cladribine PIS1M1 Cladribine PIS2M1 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Cladribine undergoes metabolism to give Cladribine PIS1M1 and Cladribine PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 Cladribine PIS2M1 Cladribine Cladribine Cladribine PIS1M1 Cladribine PIS2M1 Urinary Excretion and/or Bile duct Excretion