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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Estramustine phosphate PIS2M1 Estramustine phosphate Estramustine phosphate Estramustine phosphate PIS1M1 Estramustine phosphate PIS2M1 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Estramustine phosphate undergoes metabolism to give Estramustine phosphate PIS1M1 and Estramustine phosphate PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 Estramustine phosphate PIS2M1 Estramustine phosphate Estramustine phosphate Estramustine phosphate PIS1M1 Estramustine phosphate PIS2M1 Urinary Excretion and/or Bile duct Excretion