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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Ivacaftor PIS2M1 Ivacaftor Ivacaftor Ivacaftor PIS1M1 Ivacaftor PIS2M1 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Ivacaftor undergoes metabolism to give Ivacaftor PIS1M1 and Ivacaftor PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 Ivacaftor PIS2M1 Ivacaftor Ivacaftor Ivacaftor PIS1M1 Ivacaftor PIS2M1 Urinary Excretion and/or Bile duct Excretion