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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Nalidixic acid PIS2M1 Nalidixic Acid Nalidixic Acid Nalidixic acid PIS1M1 Nalidixic acid PIS2M1 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Nalidixic acid undergoes metabolism to give Nalidixic acid PIS1M1 and Nalidixic acid PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 Nalidixic acid PIS2M1 Nalidixic Acid Nalidixic Acid Nalidixic acid PIS1M1 Nalidixic acid PIS2M1 Urinary Excretion and/or Bile duct Excretion