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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Pirfenidone PIS2M1 Pirfenidone Pirfenidone Pirfenidone PIS1M1 Pirfenidone PIS2M1 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Pirfenidone undergoes metabolism to give Pirfenidone PIS1M1 and Pirfenidone PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 Pirfenidone PIS2M1 Pirfenidone Pirfenidone Pirfenidone PIS1M1 Pirfenidone PIS2M1 Urinary Excretion and/or Bile duct Excretion