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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Avatrombopag PIS1M1 Avatrombopag PIS1M2 Avatrombopag Avatrombopag Avatrombopag PIS1M1 Avatrombopag PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Avatrombopag undergoes metabolism to give Avatrombopag PIS1M1 and Avatrombopag PIS1M2.
Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 Avatrombopag PIS1M1 Avatrombopag PIS1M2 Avatrombopag Avatrombopag Avatrombopag PIS1M1 Avatrombopag PIS1M2 Urinary Excretion and/or Bile duct Excretion