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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Benfotiamine PIS1M1 Benfotiamine PIS1M2 Benfotiamine Benfotiamine Benfotiamine PIS1M1 Benfotiamine PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Benfotiamine undergoes metabolism to give Benfotiamine PIS1M1 and Benfotiamine PIS1M2.
Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 Benfotiamine PIS1M1 Benfotiamine PIS1M2 Benfotiamine Benfotiamine Benfotiamine PIS1M1 Benfotiamine PIS1M2 Urinary Excretion and/or Bile duct Excretion