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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Bumetanide PIS1M1 Bumetanide PIS1M2 Bumetanide Bumetanide Bumetanide PIS1M1 Bumetanide PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Bumetanide undergoes metabolism to give Bumetanide PIS1M1 and Bumetanide PIS1M2.
Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 Bumetanide PIS1M1 Bumetanide PIS1M2 Bumetanide Bumetanide Bumetanide PIS1M1 Bumetanide PIS1M2 Urinary Excretion and/or Bile duct Excretion