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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Pexidartinib PIS1M1 Pexidartinib PIS1M2 Pexidartinib Pexidartinib Pexidartinib PIS1M1 Pexidartinib PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Pexidartinib undergoes metabolism to give Pexidartinib PIS1M1 and Pexidartinib PIS1M2.
Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 Pexidartinib PIS1M1 Pexidartinib PIS1M2 Pexidartinib Pexidartinib Pexidartinib PIS1M1 Pexidartinib PIS1M2 Urinary Excretion and/or Bile duct Excretion