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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Pixantrone PIS1M1 Pixantrone PIS1M2 Pixantrone Pixantrone Pixantrone PIS1M1 Pixantrone PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Pixantrone undergoes metabolism to give Pixantrone PIS1M1 and Pixantrone PIS1M2.
Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 Pixantrone PIS1M1 Pixantrone PIS1M2 Pixantrone Pixantrone Pixantrone PIS1M1 Pixantrone PIS1M2 Urinary Excretion and/or Bile duct Excretion