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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Samidorphan PIS1M1 Samidorphan PIS1M2 Samidorphan Samidorphan Samidorphan PIS1M1 Samidorphan PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Samidorphan undergoes metabolism to give Samidorphan PIS1M1 and Samidorphan PIS1M2.
Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 Samidorphan PIS1M1 Samidorphan PIS1M2 Samidorphan Samidorphan Samidorphan PIS1M1 Samidorphan PIS1M2 Urinary Excretion and/or Bile duct Excretion