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Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Alprazolam PIS2M1 Alprazolam PIS2M1 Alprazolam PIS1M1 Alprazolam PIS1M1 Alprazolam Alprazolam Alprazolam PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Alprazolam undergoes metabolism to give Alprazolam PIS1M1, Alprazolam PIS1M2 and Alprazolam PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP3A4 CYP3A4 CYP3A4 Alprazolam PIS2M1 Alprazolam PIS2M1 Alprazolam PIS1M1 Alprazolam PIS1M1 Alprazolam Alprazolam Alprazolam PIS1M2 Urinary Excretion and/or Bile duct Excretion