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Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Amodiaquine PIS2M1 Amodiaquine PIS2M1 Amodiaquine PIS1M1 Amodiaquine PIS1M1 Amodiaquine Amodiaquine Amodiaquine PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Amodiaquine undergoes metabolism to give Amodiaquine PIS1M1, Amodiaquine PIS1M2 and Amodiaquine PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP3A4 CYP3A4 CYP3A4 Amodiaquine PIS2M1 Amodiaquine PIS2M1 Amodiaquine PIS1M1 Amodiaquine PIS1M1 Amodiaquine Amodiaquine Amodiaquine PIS1M2 Urinary Excretion and/or Bile duct Excretion