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Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Lenalidomide PIS2M1 Lenalidomide PIS2M1 Lenalidomide PIS1M1 Lenalidomide PIS1M1 Lenalidomide Lenalidomide Lenalidomide PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Lenalidomide undergoes metabolism to give Lenalidomide PIS1M1, Lenalidomide PIS1M2 and Lenalidomide PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP3A4 CYP3A4 CYP3A4 Lenalidomide PIS2M1 Lenalidomide PIS2M1 Lenalidomide PIS1M1 Lenalidomide PIS1M1 Lenalidomide Lenalidomide Lenalidomide PIS1M2 Urinary Excretion and/or Bile duct Excretion