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Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Meperidine PIS2M1 Meperidine PIS2M1 Meperidine PIS1M1 Meperidine PIS1M1 Meperidine Meperidine Meperidine PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Meperidine undergoes metabolism to give Meperidine PIS1M1, Meperidine PIS1M2 and Meperidine PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP3A4 CYP3A4 CYP3A4 Meperidine PIS2M1 Meperidine PIS2M1 Meperidine PIS1M1 Meperidine PIS1M1 Meperidine Meperidine Meperidine PIS1M2 Urinary Excretion and/or Bile duct Excretion