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Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Nebivolol PIS2M1 Nebivolol PIS2M1 Nebivolol PIS1M1 Nebivolol PIS1M1 Nebivolol Nebivolol Nebivolol PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Nebivolol undergoes metabolism to give Nebivolol PIS1M1, Nebivolol PIS1M2 and Nebivolol PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP3A4 CYP3A4 CYP3A4 Nebivolol PIS2M1 Nebivolol PIS2M1 Nebivolol PIS1M1 Nebivolol PIS1M1 Nebivolol Nebivolol Nebivolol PIS1M2 Urinary Excretion and/or Bile duct Excretion