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Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Netilmicin PIS2M1 Netilmicin PIS2M1 Netilmicin PIS1M1 Netilmicin PIS1M1 Netilmicin Netilmicin Netilmicin PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Netilmicin undergoes metabolism to give Netilmicin PIS1M1, Netilmicin PIS1M2 and Netilmicin PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP3A4 CYP3A4 CYP3A4 Netilmicin PIS2M1 Netilmicin PIS2M1 Netilmicin PIS1M1 Netilmicin PIS1M1 Netilmicin Netilmicin Netilmicin PIS1M2 Urinary Excretion and/or Bile duct Excretion