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Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Pemigatinib PIS2M1 Pemigatinib PIS2M1 Pemigatinib PIS1M1 Pemigatinib PIS1M1 Pemigatinib Pemigatinib Pemigatinib PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Pemigatinib undergoes metabolism to give Pemigatinib PIS1M1, Pemigatinib PIS1M2 and Pemigatinib PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP3A4 CYP3A4 CYP3A4 Pemigatinib PIS2M1 Pemigatinib PIS2M1 Pemigatinib PIS1M1 Pemigatinib PIS1M1 Pemigatinib Pemigatinib Pemigatinib PIS1M2 Urinary Excretion and/or Bile duct Excretion