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Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Sertindole PIS2M1 Sertindole PIS2M1 Sertindole PIS1M1 Sertindole PIS1M1 Sertindole Sertindole Sertindole PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Sertindole undergoes metabolism to give Sertindole PIS1M1, Sertindole PIS1M2 and Sertindole PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP3A4 CYP3A4 CYP3A4 Sertindole PIS2M1 Sertindole PIS2M1 Sertindole PIS1M1 Sertindole PIS1M1 Sertindole Sertindole Sertindole PIS1M2 Urinary Excretion and/or Bile duct Excretion