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Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Ambroxol Ambroxol Ambroxol PIS1M1 Ambroxol PIS1M2 Ambroxol PIS1M3 Ambroxol PIS1M3 Ambroxol PIS1M1 Ambroxol PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Ambroxol undergoes metabolism to give Ambroxol PIS1M1, Ambroxol PIS1M2 and Ambroxol PIS1M3.
Endoplasmic Reticulum Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Ambroxol Ambroxol Ambroxol PIS1M1 Ambroxol PIS1M2 Ambroxol PIS1M3 Ambroxol PIS1M3 Ambroxol PIS1M1 Ambroxol PIS1M2 Urinary Excretion and/or Bile duct Excretion