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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Methylphenobarbital Methylphenobarbital Methylphenobarbital PIS1M2 Methylphenobarbital PIS2M1 Methylphenobarbital PIS2M1 Methylphenobarbital PIS1M1 Methylphenobarbital PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Methylphenobarbital undergoes metabolism to give Methylphenobarbital PIS1M1, Methylphenobarbital PIS1M2 and Methylphenobarbital PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Methylphenobarbital Methylphenobarbital Methylphenobarbital PIS1M2 Methylphenobarbital PIS2M1 Methylphenobarbital PIS2M1 Methylphenobarbital PIS1M1 Methylphenobarbital PIS1M2 Urinary Excretion and/or Bile duct Excretion