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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Methylprednisone Methylprednisone Methylprednisone PIS1M2 Methylprednisone PIS2M1 Methylprednisone PIS2M1 Methylprednisone PIS1M1 Methylprednisone PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Methylprednisone undergoes metabolism to give Methylprednisone PIS1M1, Methylprednisone PIS1M2 and Methylprednisone PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Methylprednisone Methylprednisone Methylprednisone PIS1M2 Methylprednisone PIS2M1 Methylprednisone PIS2M1 Methylprednisone PIS1M1 Methylprednisone PIS1M2 Urinary Excretion and/or Bile duct Excretion