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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Netupitant Netupitant Netupitant PIS1M2 Netupitant PIS2M1 Netupitant PIS2M1 Netupitant PIS1M1 Netupitant PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Netupitant undergoes metabolism to give Netupitant PIS1M1, Netupitant PIS1M2 and Netupitant PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Netupitant Netupitant Netupitant PIS1M2 Netupitant PIS2M1 Netupitant PIS2M1 Netupitant PIS1M1 Netupitant PIS1M2 Urinary Excretion and/or Bile duct Excretion