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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Sertaconazole Sertaconazole Sertaconazole PIS1M2 Sertaconazole PIS2M1 Sertaconazole PIS2M1 Sertaconazole PIS1M1 Sertaconazole PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Sertaconazole undergoes metabolism to give Sertaconazole PIS1M1, Sertaconazole PIS1M2 and Sertaconazole PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Sertaconazole Sertaconazole Sertaconazole PIS1M2 Sertaconazole PIS2M1 Sertaconazole PIS2M1 Sertaconazole PIS1M1 Sertaconazole PIS1M2 Urinary Excretion and/or Bile duct Excretion