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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Tiaprofenic acid Tiaprofenic acid Tiaprofenic acid PIS1M2 Tiaprofenic acid PIS2M1 Tiaprofenic acid PIS2M1 Tiaprofenic acid PIS1M1 Tiaprofenic acid PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Tiaprofenic acid undergoes metabolism to give Tiaprofenic acid PIS1M1, Tiaprofenic acid PIS1M2 and Tiaprofenic acid PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Tiaprofenic acid Tiaprofenic acid Tiaprofenic acid PIS1M2 Tiaprofenic acid PIS2M1 Tiaprofenic acid PIS2M1 Tiaprofenic acid PIS1M1 Tiaprofenic acid PIS1M2 Urinary Excretion and/or Bile duct Excretion