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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Triprolidine Triprolidine Triprolidine PIS1M2 Triprolidine PIS2M1 Triprolidine PIS2M1 Triprolidine PIS1M1 Triprolidine PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Triprolidine undergoes metabolism to give Triprolidine PIS1M1, Triprolidine PIS1M2 and Triprolidine PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Triprolidine Triprolidine Triprolidine PIS1M2 Triprolidine PIS2M1 Triprolidine PIS2M1 Triprolidine PIS1M1 Triprolidine PIS1M2 Urinary Excretion and/or Bile duct Excretion