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Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Minaprine Minaprine Minaprine PIS1M2 Minaprine PIS1M3 Minaprine PIS1M3 Minaprine PIS2M1 Minaprine PIS2M1 Minaprine PIS1M1 Minaprine PIS1M2 Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Minaprine undergoes metabolism to give Minaprine PIS1M1, Minaprine PIS1M2, Minaprine PIS1M3 and Minaprine PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 Minaprine Minaprine Minaprine PIS1M2 Minaprine PIS1M3 Minaprine PIS1M3 Minaprine PIS2M1 Minaprine PIS2M1 Minaprine PIS1M1 Minaprine PIS1M2 Urinary Excretion and/or Bile duct Excretion