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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Miltefosine PIS1M3 Miltefosine PIS1M3 Miltefosine PIS1M1 Miltefosine PIS1M1 Miltefosine Miltefosine Miltefosine PIS2M1 Miltefosine PIS2M1 Miltefosine PIS1M2 Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Miltefosine undergoes metabolism to give Miltefosine PIS1M1, Miltefosine PIS1M2, Miltefosine PIS1M3 and Miltefosine PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 Miltefosine PIS1M3 Miltefosine PIS1M3 Miltefosine PIS1M1 Miltefosine PIS1M1 Miltefosine Miltefosine Miltefosine PIS2M1 Miltefosine PIS2M1 Miltefosine PIS1M2 Urinary Excretion and/or Bile duct Excretion