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Unknown Unknown Unknown Unknown Cytochrome P450 1A2 Cytochrome P450 1A2 Cytochrome P450 1A2 Cytochrome P450 3A4 Almitrine Almitrine Almitrine PIS1M2 Almitrine PIS2M2 Almitrine PIS2M2 Almitrine PIS2M1 Almitrine PIS2M1 Almitrine PIS1M1 Almitrine PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Heme Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Almitrine undergoes metabolism to give Almitrine PIS1M1, Almitrine PIS1M2, Almitrine PIS1M3 and Almitrine PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown CYP1A2 CYP1A2 CYP1A2 CYP3A4 Almitrine Almitrine Almitrine PIS1M2 Almitrine PIS2M2 Almitrine PIS2M2 Almitrine PIS2M1 Almitrine PIS2M1 Almitrine PIS1M1 Almitrine PIS1M2 Urinary Excretion and/or Bile duct Excretion