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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Metaraminol PIS1M1 Metaraminol PIS1M1 Metaraminol Metaraminol Metaraminol PIS1M2 Metaraminol PIS2M1 Metaraminol PIS2M1 Metaraminol PIS1M2 Metaraminol PIS1M3 Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Metaraminol undergoes metabolism to give Metaraminol PIS1M1, Metaraminol PIS1M2, Metaraminol PIS1M3 and Metaraminol PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 Metaraminol PIS1M1 Metaraminol PIS1M1 Metaraminol Metaraminol Metaraminol PIS1M2 Metaraminol PIS2M1 Metaraminol PIS2M1 Metaraminol PIS1M2 Metaraminol PIS1M3 Urinary Excretion and/or Bile duct Excretion