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Unknown Unknown Unknown Cytochrome P450 1A2 Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 3A4 Omadacycline Omadacycline Omadacycline PIS1M2 Omadacycline PIS4M1 Omadacycline PIS4M1 Omadacycline PIS1M1 Omadacycline PIS1M2 Omadacycline PIS2M1 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Omadacycline undergoes metabolism to give Omadacycline PIS1M1, Omadacycline PIS1M2, Omadacycline PIS1M3 and Omadacycline PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP1A2 CYP1A2 CYP3A4 CYP3A4 Omadacycline Omadacycline Omadacycline PIS1M2 Omadacycline PIS4M1 Omadacycline PIS4M1 Omadacycline PIS1M1 Omadacycline PIS1M2 Omadacycline PIS2M1 Urinary Excretion and/or Bile duct Excretion