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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Patent Blue Patent Blue Patent Blue PIS4M1 Patent Blue PIS4M1 Patent Blue PIS2M1 Patent Blue PIS2M1 Patent Blue PIS1M1 Patent Blue PIS2M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Patent Blue undergoes metabolism to give Patent Blue PIS1M1, Patent Blue PIS2M1 and Patent Blue PIS4M1. Endoplasmic Reticulum Many other Cytochrome P450 enzymes are involved in Phase I (PI) Step 1(S1) and Step 2(S2) reactions.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 Patent Blue Patent Blue Patent Blue PIS4M1 Patent Blue PIS4M1 Patent Blue PIS2M1 Patent Blue PIS2M1 Patent Blue PIS1M1 Patent Blue PIS2M2 Urinary Excretion and/or Bile duct Excretion