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Unknown Unknown Unknown Unknown Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 3A4 Besifloxacin Besifloxacin Besifloxacin PIS2M2 Besifloxacin PIS2M2 Besifloxacin PIS2M1 Besifloxacin PIS2M1 Besifloxacin PIS1M1 Besifloxacin PIS1M1 Besifloxacin PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Besifloxacin undergoes metabolism to give Besifloxacin PIS1M1, Besifloxacin PIS1M2, Besifloxacin PIS1M3 and Besifloxacin PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown CYP1A2 CYP3A4 CYP3A4 Besifloxacin Besifloxacin Besifloxacin PIS2M2 Besifloxacin PIS2M2 Besifloxacin PIS2M1 Besifloxacin PIS2M1 Besifloxacin PIS1M1 Besifloxacin PIS1M1 Besifloxacin PIS1M2 Urinary Excretion and/or Bile duct Excretion