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Unknown Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 2C9 Tacrine Tacrine Tacrine PIS1M2 Tacrine PIS1M3 Tacrine PIS1M3 Tacrine PIS1M1 Tacrine PIS1M1 Tacrine PIS1M4 Tacrine PIS1M4 Tacrine PIS1M5 Tacrine PIS1M5 Tacrine PIS1M2 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Tacrine undergoes metabolism to give Tacrine PIS1M1, Tacrine PIS1M2, Tacrine PIS1M3, Tacrine PIS1M4 and Tacrine PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP2C9 Tacrine Tacrine Tacrine PIS1M2 Tacrine PIS1M3 Tacrine PIS1M3 Tacrine PIS1M1 Tacrine PIS1M1 Tacrine PIS1M4 Tacrine PIS1M4 Tacrine PIS1M5 Tacrine PIS1M5 Tacrine PIS1M2 Urinary Excretion and/or Bile duct Excretion