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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Fexinidazole Fexinidazole Fexinidazole PIS2M2 Fexinidazole PIS2M2 Fexinidazole PIS4M1 Fexinidazole PIS4M1 Fexinidazole PIS1M1 Fexinidazole PIS2M1 Fexinidazole PIS1M2 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Fexinidazole undergoes metabolism to give Fexinidazole PIS1M1, Fexinidazole PIS1M2, Fexinidazole PIS1M3, Fexinidazole PIS1M4 and Fexinidazole PIS2M1. Endoplasmic Reticulum Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Fexinidazole Fexinidazole Fexinidazole PIS2M2 Fexinidazole PIS2M2 Fexinidazole PIS4M1 Fexinidazole PIS4M1 Fexinidazole PIS1M1 Fexinidazole PIS2M1 Fexinidazole PIS1M2 Urinary Excretion and/or Bile duct Excretion